Classification and Prevalence of Pigmented Lesions in Patients with Total-Body Photographs at High Risk of Developing Melanoma

Abstract

Background: The classification of many pigmented lesions is not well defined, and an association with melanoma has not been established. Objective: To better define the spectrum of pigmented lesions (excluding common and dysplastic nevi) and explore links to melanoma. Methods: Retrospective review of patients with total-body digital photographs at high risk of developing melanoma from the Memorial Sloan-Kettering Cancer Center Dermatology Service. Results: Among 598 patients, 7.7% had café au lait spots, 2.8% had nevi spilus, 2.3% had congenital nevus–like nevi, 2% had “other” lesions, 1.2% had segmental speckled lentiginous nevi, and 1% had agminated nevi. There was no statistical difference in the prevalence rates of these pigmented lesions in patients with or without a history of melanoma or > 100 nevi. Conclusions: A wide range of pigmented lesions require further classification and study to explore possible links to melanoma.