CORRELATION OF POINCARE PLOT DERIVED STRESS SCORE AND HEART RATE VARIABILITY PARAMETERS IN THE ASSESSMENT OF CORONARY ARTERY DISEASE

Abstract

Atherosclerosis-generated coronary artery disease (CAD) causes the anomaly of autonomic activity. The assessment of autonomic balance under disease conditions is of clinical interest. Thus, this work aimed to evaluate the CAD using Poincare-derived stress score (SS) and sympathetic/sympathetic-parasympathetic (S/PS). A total of 60 male (50–55 years) volunteers including CAD ([Formula: see text]=30) and control ([Formula: see text]=30) participated in this work. Digital lead-II electrocardiogram (ECG) was recorded for 10 min in a supine position and filtered to remove noises. A total of 10 tachogram samples were computed from each subject for a 5 min ECG signal duration with a shift of 30 s on the processed signal using Acqknowledge 4.0 (Biopac Systems Inc., USA). The heart rate variability (HRV) parameters were computed from the obtained tachogram. The computed Poincare plot parameters were used to derive the SS and S/PS ratios. The regression model was employed to observe the correlation of SS and S/PS to the HRV parameters. The obtained results revealed reduced HRV with higher sympathetic and reduced parasympathetic activity under CAD than the control subjects. The autonomic dysfunction was observed with significantly higher values of SS and S/PS in CAD than in the control subjects. The S/PS was observed to be positively associated with LF/HF and SD2/SD1 parameters. While SS was found to be positively correlated to the LF and LF/HF parameters in CAD and control subjects. The obtained linear strong correlation of SS and S/PS with control and CAD subjects suggested the use of SS and S/PS as excellent sympathetic activity and sympathovagal balance markers.