Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)-Reference-Cited by-同舟云学术

Analysis of influence of background therapy for comorbidities in the period before infection on the risk of the lethal COVID outcome. Data from the international ACTIV SARS-CoV-2 registry («Analysis of chronic non-infectious diseases dynamics after COVID-19 infection in adult patients SARS-CoV-2»)

Published:2021-09-30 Issue:9 Volume:61 Page:20-32
ISSN:2412-5660
Container-title:Kardiologiia
language:
Short-container-title:Kardiologiia

Author:

Tarlovskaya E. I.¹^ORCID,Arutyunov A. G.²^ORCID,Konradi A. O.³^ORCID,Lopatin Yu. M.⁴^ORCID,Rebrov A. P.⁵^ORCID,Tereshchenko S. N.⁶^ORCID,Chesnikova A. I.⁷^ORCID,Hayrapetyan H. G.⁸^ORCID,Babin A. P.⁹,Bakulin I. G.¹⁰^ORCID,Bakulina N. V.¹⁰^ORCID,Balykova L. A.¹¹^ORCID,Blagonravova A. S.¹²^ORCID,Boldina M. V.¹²^ORCID,Vaisberg A. R.¹²^ORCID,Galyavich A. S.¹³^ORCID,Gomonova V. V.¹⁰^ORCID,Grigorieva N. Yu.¹⁴^ORCID,Gubareva I. V.¹⁵^ORCID,Demko I. V.¹⁶^ORCID,Evzerikhina A. V.¹⁷,Zharkov A. V.¹⁸^ORCID,Kamilova U. K.¹⁹^ORCID,Kim Z. F.²⁰^ORCID,Kuznetsova T. Yu.²¹^ORCID,Lareva N. V.²²^ORCID,Makarova E. V.¹²^ORCID,Malchikova S. V.²³^ORCID,Nedogoda S. V.⁴^ORCID,Petrova M. M.²⁴^ORCID,Pochinka I. G.²⁵^ORCID,Protasov K. V.²⁶^ORCID,Protsenko D. N.²⁷^ORCID,Ruzanau D. Yu.²⁸^ORCID,Sayganov S. A.¹⁰^ORCID,Sarybaev A. S.²⁹^ORCID,Selezneva N. M.¹¹^ORCID,Sugraliev A. B.³⁰^ORCID,Fomin I. V.¹²^ORCID,Khlynova O. V.³¹^ORCID,Chizhova O. Yu.¹⁰^ORCID,Shaposhnik I. I.³²^ORCID,Shсukarev D. A.¹⁸,Abdrahmanova A. K.³³^ORCID,Avetisian S. A.⁸,Avoyan H. G.⁸^ORCID,Azarian K. K.⁸,Aimakhanova G. T.³⁰,Ayipova D. A.²⁹,Akunov A. Ch.²⁹,Alieva M. K.¹⁰^ORCID,Aparkina A. V.⁵^ORCID,Aruslanova O. R.³⁴^ORCID,Ashina E. Yu.¹²^ORCID,Badina O. Yu.³⁵^ORCID,Barisheva O. Yu.²¹^ORCID,Batchayeva A. S.³⁶,Bitieva A. M.¹⁰^ORCID,Bikhteyev I. U.¹⁰^ORCID,Borodulina N. A.³⁴^ORCID,Bragin M. V.¹⁰^ORCID,Budu A. M.³⁷,Burygina L. A.³⁸^ORCID,Bykova G. A.³¹^ORCID,Vagapova K. R.³⁹,Varlamova D. D.²¹^ORCID,Vezikova N. N.²¹^ORCID,Verbitskaya E. A.²⁴^ORCID,Vilkova O. E.¹⁴^ORCID,Vinnikova E. A.¹⁰^ORCID,Vustina V. V.⁴⁰^ORCID,Gаlova E. A.¹²^ORCID,Genkel V. V.³²^ORCID,Gorshenina E. I.¹¹,Gostishev R. V.²⁷^ORCID,Grigorieva E. V.⁵^ORCID,Gubareva E. Yu.¹⁵^ORCID,Dabylova G. M.³⁰,Demchenko A. I.¹⁵,Dolgikh O. Yu.⁴¹,Duyshobayev M. Y.³⁰,Evdokimov D. S.¹⁰^ORCID,Egorova K. E.⁴²^ORCID,Ermilova A. N.⁴³^ORCID,Zheldybayeva A. E.³⁰,Zarechnova N. V.³⁵,Zimina Yu. D.⁴⁴^ORCID,Ivanova S. Yu.⁴⁵^ORCID,Ivanchenko E. Yu.¹²^ORCID,Ilina M. V.⁴⁶^ORCID,Kazakovtseva M. V.²³^ORCID,Kazymova E. V.⁴⁷,Kalinina Yu. S.²⁴^ORCID,Kamardina N. A.³⁵,Karachenova A. M.²²^ORCID,Karetnikov I. A.⁴⁸^ORCID,Karoli N. A.⁵^ORCID,Karpov O. V.⁴⁹^ORCID,Karsiev M. Kh.¹⁰^ORCID,Кaskaeva D. S.²⁴^ORCID,Kasymova K. F.²⁴^ORCID,Kerimbekova Zh. B.²⁹,Kerimova A. Sh.²⁷^ORCID,Kim E. S.⁵⁰,Kiseleva N. V.¹²^ORCID,Klimenko D. A.¹⁵,Klimova A. V.⁵¹^ORCID,Kovalishena O. V.¹²^ORCID,Kolmakova E. V.¹⁰,Kolchinskaya T. P.⁵²,Kolyadich M. I.⁵³^ORCID,Kondriakova O. V.¹⁵^ORCID,Konoval M. P.¹⁰^ORCID,Konstantinov D. Yu.¹⁵^ORCID,Konstantinova E. A.¹⁵^ORCID,Kordukova V. A.¹²,Koroleva E. V.⁵⁴,Kraposhina A. Yu.⁵⁵^ORCID,Kriukova T. V.⁵⁶,Kuznetsova A. S.³²^ORCID,Kuzmina T. Yu.²⁴^ORCID,Kuzmichev K. V.⁵⁷,Kulchoroeva Ch. K.²⁹^ORCID,Kuprina T. V.²¹^ORCID,Kouranova I. M.⁵⁸,Kurenkova L. V.⁵⁹,Kurchugina N. Yu.¹⁵^ORCID,Kushubakova N. A.²⁹^ORCID,Levankova V. I.⁶⁰^ORCID,Levin M. Е.³⁸^ORCID,Lyubavina N. A.¹²^ORCID,Magdeyeva N. A.⁵^ORCID,Mazalov K. V.³⁵,Majseenko V. I.⁶¹^ORCID,Makarova A. S.²⁶^ORCID,Maripov A. M.²⁹^ORCID,Marusina A. A.⁴⁶^ORCID,Melnikov E. S.⁶²^ORCID,Moiseenko N. B.¹⁴^ORCID,Muradova F. N.¹²^ORCID,Muradyan R. G.⁶³,Myshak A. O.⁶⁴,Nikitina N. M.⁵^ORCID,Ogurlieva B. B.⁶⁵,Odegova A. A.²³^ORCID,Omarova Yu. M.¹²^ORCID,Omurzakova N. A.²⁹^ORCID,Ospanova Sh. O.³⁰,Pahomova E. V.⁶⁶^ORCID,Petrov L. D.⁶⁷,Plastinina S. S.¹²^ORCID,Pogrebetskaya V. A.⁶⁸,Polyakov D. S.¹²^ORCID,Ponomarenko E. V.⁶⁹,Popova L. L.¹⁵^ORCID,Prokofeva N. A.¹⁰^ORCID,Pudova I. A.⁷⁰,Rakov N. A.¹²,Rakhimov A. N.⁷¹,Rozanova N. A.¹⁷,Serikbolkyzy S.³⁰,Simonov A. A.¹⁰^ORCID,Skachkova V. V.⁴⁰^ORCID,Soloveva D. V.¹²^ORCID,Soloveva I. A.⁵⁵^ORCID,Sokhova F. M.³⁸^ORCID,Subbotin A. K.³⁵,Sukhomlinova I. M.⁷²,Sushilova A. G.¹⁰^ORCID,Tagayeva D. R.¹⁹,Titojkina Yu. V.¹¹^ORCID,Tikhonova E. P.²⁴^ORCID,Tokmin D. S.⁷³,Tolmacheva A. A.⁷⁴^ORCID,Torgunakova M. S.²⁴^ORCID,Trenogina K. V.⁴⁰^ORCID,Trostianetckaia N. A.¹⁰,Trofimov D. A.⁷⁵^ORCID,Tulichev A. A.⁷⁶^ORCID,Tursunova A. T.³⁰,Ulanova N. D.⁷⁷^ORCID,Fatenkov O. V.¹⁵^ORCID,Fedorishina O. V.²⁶^ORCID,Fil T. S.¹⁰,Fomina I. Yu.⁷⁸,Fominova I. S.¹¹,Frolova I. A.³⁵,Tsvinger S. M.²²^ORCID,Tsoma V. V.⁴^ORCID,Cholponbaeva M. B.⁷⁹,Chudinovskikh T. I.²³^ORCID,Shevchenko O. A.⁸⁰,Sheshina T. V.¹⁴,Shishkina E. A.³¹^ORCID,Shishkov K. Yu.¹⁵^ORCID,Sherbakov S. Yu.⁸¹,Yausheva E. A.¹¹,Musaelian Sh. N.⁸²,Belenkov Yu. N.⁸³^ORCID,Arutyunov G. P.²

Affiliation:

1. Eurasian Association of Therapists, Moscow; Privolzhsky Research Medical University, Nizhny Novgorod

2. Eurasian Association of Therapists, Moscow; N. I. Pirogov Russian National Research Medical University, Moscow

3. V. A. Almazov National Medical Research Center, St. Peterburg

4. Volgograd State Medical University, Volgograd

5. V. I. Razumovsky Saratov State Medical University, Saratov

6. National Medical Research Center of Cardiology, Moscow

7. Rostov State Medical University, Rostov-on-Don

8. Erebouni Medical Center, Cardiology and Cardiac Surgery Clinic, Erevan

9. Nikolae Testemitanu Sate University of Medicine and Pharmacy, Kishinev

10. I. I. Mechnikov North-Western State Medical University, St. Petersburg

11. N. P. Ogarev National Research Mordovia State University, Saransk

12. Privolzhsky Research Medical University, Nizhny Novgorod

13. Interregional Clinical Diagnostic Center, Kazan; Kazan State Medical University, Kazan

14. N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod

15. Samara State Medical University, Samara

16. Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk

17. Krasnogorsk Municipal Hospital №1, Krasnogorsk

18. Kirovsk Inter-District Hospital, Kirovsk

19. National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent

20. Kazan Municipal Clinical Hospital №7, Kazan

21. Petrozavodsk State University, Petrozavodsk

22. Chita State Medical Academy, Chita

23. Kirov State Medical University, Kirov

24. Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk

25. Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod

26. Irkutsk State Medical Academy of Postgraduate Education, Branch of the Russian Medical Academy of Continuing Professional Education, Irkutsk

27. Municipal Clinical Hospital №40, Moscow

28. Gomel State Medical University, Gome

29. M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek

30. S. D. Asfendiyarov Kazakh National Medical University, Alma-Ata

31. Akademician E. A. Vagner Perm State Medical University, Perm

32. South Ural State Medical University, Chelyabinsk

33. Kazakh Medical University of Continuous Education, Alma-Ata; I. Zhekenova Municipal Clinical Hospital for Infectious Diseases, Alma-Ata

34. Clinical Cardiological Center, Perm

35. Privolzhsky District Medical Center, Nizhny Novgorod

36. N. I. Pirogov Russian National Research Medical University, Moscow

37. Municipal Clinical Hospital №1, Kishinev

38. P. B. Gannushkin Psychiatric Clinical Hospital №4, Moscow

39. Polyclinic №1 at the Administrative Department of the President of the Russian Federation, Moscow

40. Perm Regional Clinical Hospital, Perm

41. Chapaevsk Central Municipal Hospital, Chapaevsk

42. V. A Baranov Karelia Republic Hospital, Petrozavodsk

43. Eurasian Association of Therapists, Moscow; V. P. Serbsky National Medical Research Center of Psychiatry and Narcology, Moscow

44. Municipal Clinical Hospital №25, Novosibirsk

45. Hospital for Veterans of Wars, Petrozavodsk

46. Kirovsk Inter-District Hospital, outpatient department, Kirovsk

47. Clinical Hospital at the Samara Station “Russian Railways Medicine”, Samara

48. Irkutsk Regional Clinical Hospital, recipient of the “Badge of Honor” award, Irkutsk

49. P. B. Gannushkin Psychiatric Clinical Hospital #4, Moscow

50. Kazan State Medical University, Kazan; Kazan Municipal Clinical Hospital №7, Kazan

51. N. I. Pirogov Russian National Research Medical University, Moscow; Municipal Polyclinic №134, Moscow

52. Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk

53. South Ural State Medical University, Chelyabinsk; Chelyabinsk Municipal Clinical Hospital №1, Chelyabinsk

54. Municipal Clinical Hospital №5 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod

55. Krasnoyarsk Regional Clinical Hospital, Krasnoyarsk; Prof. V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk

56. Eurasian Association of Therapists, Moscow

57. Municipal Clinical Hospital №13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod

58. Gorodets Central Regional Hospital, Gorodets

59. S. V. Katkov Mordovian Clinical Hospital, Saransk

60. Municipal Polyclinic №1, Petrozavodsk

61. Gomel State Medical University, Gomel

62. Eurasian Association of Therapists, Moscow; I. I. Mechnikov North-Western State Medical University, St. Petersburg

63. Global Medical System Clinics and Hospitals, Moscow

64. MedInvestGroup LLC, Moscow

65. N. I. Pirogov Russian National Research Medical University, Moscow; Municipal Clinical Hospital №4, Moscow

66. GBUZ RK "Republican tuberculosis dispensary", Petrozavodsk

67. Health Center Brichen, Brichen

68. Municipal Clinical Hospital №38 of the Nizhny Novgorod Nizhegorodsky District, Nizhny Novgorod

69. Medical Center “Zimamed”, Krasnodar

70. Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Polyclinic №4 of the Nizhny Novgorod Kanavinsky District, Nizhny Novgorod

71. 21 National Specialized Science and Practice Medical Center for Therapy and Medical Rehabilitation, Tashkent

72. Hospital for Veterans of Wars, St. Petersburg

73. AO “Laboratories of the Future”, Moscow

74. Novosibirsk State Medical University, Novosibirsk; Clinical Consultative and Diagnostic Polyclinic №27, Novosibirsk

75. Kazan State Medical University, Kazan; Kazan Municipal Clinical Hospital №7, Kazan

76. Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Clinical Hospital №3, Nizhny Novgorod

77. Municipal Clinical Hospital #13 of the Nizhny Novgorod Avtozavodsky District, Nizhny Novgorod

78. Privolzhsky Research Medical University, Nizhny Novgorod; Municipal Polyclinic #1, Nizhny Novgorod

79. M. M. Mirrakhimov National Center of Cardiology and Therapy, Bishkek,

80. Samara Municipal Polyclinic №3, Samara

81. Kazan State Medical Academy, Branch of the Russian Medical Academy of Continuing Professional Education, Kazan

82. Erevan State Medical University, Erevan

83. The First Moscow state medical University I. M. Sechenov

Abstract

Aim To study the effect of regular drug therapy for cardiovascular and other diseases preceding the COVID-19 infection on severity and outcome of COVID-19 based on data of the ACTIVE (Analysis of dynamics of Comorbidities in paTIents who surVived SARS-CoV-2 infEction) registry.Material and methods The ACTIVE registry was created at the initiative of the Eurasian Association of Therapists. The registry includes 5 808 male and female patients diagnosed with COVID-19 treated in a hospital or at home with a due protection of patients’ privacy (data of nasal and throat smears; antibody titer; typical CT imaging features). The register territory included 7 countries: the Russian Federation, the Republic of Armenia, the Republic of Belarus, the Republic of Kazakhstan, the Kyrgyz Republic, the Republic of Moldova, and the Republic of Uzbekistan. The registry design: a closed, multicenter registry with two nonoverlapping arms (outpatient arm and in-patient arm). The registry scheduled 6 visits, 3 in-person visits during the acute period and 3 virtual visits (telephone calls) at 3, 6, and 12 mos. Patient enrollment started on June 29, 2020 and was completed on October 29, 2020. The registry completion is scheduled for October 29, 2022. The registry ID: ClinicalTrials.gov: NCT04492384. In this fragment of the study of registry data, the work group analyzed the effect of therapy for comorbidities at baseline on severity and outcomes of the novel coronavirus infection. The study population included only the patients who took their medicines on a regular basis while the comparison population consisted of noncompliant patients (irregular drug intake or not taking drugs at all despite indications for the treatment).Results The analysis of the ACTIVE registry database included 5808 patients. The vast majority of patients with COVID-19 had comorbidities with prevalence of cardiovascular diseases. Medicines used for the treatment of COVID-19 comorbidities influenced the course of the infectious disease in different ways. A lower risk of fatal outcome was associated with the statin treatment in patients with ischemic heart disease (IHD); with angiotensin-converting enzyme inhibitors (ACEI)/angiotensin receptor antagonists and with beta-blockers in patients with IHD, arterial hypertension, chronic heart failure (CHF), and atrial fibrillation; with oral anticoagulants (OAC), primarily direct OAC, clopidogrel/prasugrel/ticagrelor in patients with IHD; with oral antihyperglycemic therapy in patients with type 2 diabetes mellitus (DM); and with long-acting insulins in patients with type 1 DM. A higher risk of fatal outcome was associated with the spironolactone treatment in patients with CHF and with inhaled corticosteroids (iCS) in patients with chronic obstructive pulmonary disease (COPD).Conclusion In the epoch of COVID-19 pandemic, a lower risk of severe course of the coronavirus infection was observed for patients with chronic noninfectious comorbidities highly compliant with the base treatment of the comorbidity.

Publisher

APO Society of Specialists in Heart Failure

Subject

Cardiology and Cardiovascular Medicine

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Direct Oral Anticoagulants’ Consumption and Expenditure in the COVID-19 Pandemic in Russia and Clinical Practice Guidelines for Their Use;Pharmacoepidemiology;2023-12-29

2. Clinical course and consequences of coronavirus infection in patients with arterial hypertension;Bulletin Physiology and Pathology of Respiration;2023-07-06

3. Association of Cardiovascular Medications With Adverse Outcomes in a Matched Analysis of a National Cohort of Patients With COVID-19;American Journal of Medicine Open;2023-06

4. The problem of cross risk of arterial hypertension progression, obstructive sleep apnea syndrome and COVID-19;Russian Journal of Cardiology;2023-05-21

5. Factors associated with adverse outcome among hospitalized patients with moderate to severe COVID-19;Kachestvennaya Klinicheskaya Praktika = Good Clinical Practice;2023-04-19