Affiliation:
1. Resort Cardiology Clinic “Chernaya Rechka (Black River)”
2. Research Clinical and Educational Center “Kardiologiya (Cardiology)”, Medical School of the Saint Petersburg State University
Abstract
This review focuses on the participation of von Willebrand factor (VWF), that considerably contributes to thrombogenesis in damaged blood vessels, in the pathogenesis of atherosclerosis-induced cardiovascular pathology. Excessive formation and dysfunction of VWF leads to intravascular thrombosis and facilitates the development of endothelial dysfunction, vascular inflammation, and, thereby, the initiation and progression of atherosclerosis. The review presents information based on the analysis of full-text publications from PubMed that address the role of VWF in the development of atherosclerosis and its complications as well as the potential for influencing this index.
Publisher
APO Society of Specialists in Heart Failure
Subject
Cardiology and Cardiovascular Medicine