Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats-Reference-Cited by-同舟云学术

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Effect of glutathione (GSH) depletion on DNA damage and blood chemistry in aged and young rats

Published:2008 Issue:4 Volume:33 Page:421-429
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Hashimoto Kazuyuki¹²³,Takasaki Wataru³,Yamoto Takashi³,Manabe Sunao³,Sato Itaru¹²,Tsuda Shuji¹²

Affiliation:

1. Department of Applied Veterinary Science, The Doctoral Course of the United Graduate School of Veterinary Science, Gifu University

2. Laboratory of Veterinary Public Health, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University

3. Medicinal Safety Laboratories, Daiichi Sankyo Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

http://www.jstage.jst.go.jp/article/jts/33/4/33_4_421/_pdf

Reference30 articles.

1. Cabelof, D.C., Raffoul, J.J., Ge, Y., Van Remmen, H., Matherly, L.H. and Heydari, A.R. (2006): Age-related loss of the DNA repair response following exposure to oxidative stress. J. Gerontol. A. Biol. Sci. Med. Sci., 61, 427-434.

2. Chung, F.L., Komninou, D., Zhang, L., Nath, R., Pan, J., Amin, S. and Richie, J. (2005): Glutathione depletion enhances the formation of endogenous cyclic DNA adducts derived from t-4-hydroxy-2-nonenal in rat liver. Chem. Res. Toxicol., 18, 24-27.

3. de la Asuncion, J.G., Millan, A., Pla, R., Bruseghini, L., Esteras, A., Pallardo, F.V., Sastre, J. and Vina, J. (1996): Mitochondrial glutathione oxidation correlates with age-associated oxidative damage to mitochondrial DNA. FASEB J., 10, 333-338.

4. Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

5. Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

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