Male-specific prolongation of prothombin time by industrial chemicals

Author:

Yamada Takashi1,Tanaka Yushiro2,Hasegawa Ryuichi2,Igarashi Toshime1,Hirose Akihiko1

Affiliation:

1. Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences

2. Chemical Management Center, National Institute of Technology and Evaluation

Publisher

Japanese Society of Toxicology

Reference40 articles.

1. Abe, T., Kobayashi, K., Nishikawa, S., Yamada, T., Hasegawa, R., Sakuratani, Y., Yamada, J., Hirose, A., Kamata, E., Yoshida, M., Sunouchi, M., Honma, M., Yamashita, T., Sakai, K., Yamazoe, Y. and Hayashi, M. (2012): Development of Hazard Evaluation Support System (HESS). Pharm stage, 12, 39-47.

2. Fasco, M.J., Hildebrandt, E.F. and Suttie, J.W. (1982): Evidence that warfarin anticoagulant action involves two distinct reductase activities. J. Biol. Chem., 257, 11210-11212.

3. Hara, K., Akiyama, Y. and Tajima, T. (1994): Sex differences in the anticoagulant effects of warfarin. Jpn. J. Pharmacol., 66, 387-392.

4. Jolly, D.W., Craig, C. and Nelson, T.E. Jr. (1977): Estrogen and prothrombin synthesis: effect of estrogen on absorption of vitamin K1. Am. J. Physiol., 232, H12-17.

5. Khoury, G. and Sheikh-Taha, M. (2014): Effect of age and sex on warfarin dosing. Clin. Pharmacol., 6, 103-106.

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