Activation of Akt–cAMP response element-binding protein (CREB) signaling as an adaptive response to an electrophilic metabolite of morphine
Author:
Affiliation:
1. Faculty of Pharmaceutical Sciences, Fukuoka University
2. Graduate School of Biomedical Sciences, Nagasaki University
3. Graduate School of Pharmaceutical Sciences, Kyushu University
Publisher
Japanese Society of Toxicology
Link
https://www.jstage.jst.go.jp/article/fts/11/2/11_79/_pdf
Reference30 articles.
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2. Abiko, Y., Shinkai, Y., Unoki, T., Hirose, R., Uehara, T. and Kumagai, Y. (2017b): Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Sci. Rep., 7, 4814.
3. Bercovitch, M. and Adunsky, A. (2004): Patterns of high-dose morphine use in a home-care hospice service: should we be afraid of it? Cancer, 101, 1473-1477.
4. Boise, L.H., González-García, M., Postema, C.E., Ding, L., Lindsten, T., Turka, L.A., Mao, X., Nuñez, G. and Thompson, C.B. (1993): bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell, 74, 597-608.
5. Covey, T.M., Edes, K., Coombs, G.S., Virshup, D.M. and Fitzpatrick, F.A. (2010): Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. PLoS One, 5, e13545.
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