Flunitrazepam alters the toxicokinetics of chlorpromazine enhancing its toxicity

Author:

Nakajima Kota1,Kaizaki-Mitsumoto Asuka1,Numazawa Satoshi1

Affiliation:

1. Department of ToxicologyShowa University Graduate School of Pharmacy

Publisher

Japanese Society of Toxicology

Subject

General Medicine

Reference26 articles.

1. Boschi, G., Launay, N. and Rips, R. (1987): Neuroleptic-induced hypothermia in mice: lack of evidence for a central mechanism. Br. J. Pharmacol., 90, 745-751.

2. Dingell, J.V. and Sossi, N. (1977): Studies on the glucuronidation of 7-hydroxychlorpromazine in vitro. Drug Metab. Dispos., 5, 397-404.

3. Evaluation and licensing division, pharmaceutical and food safety bureau, ministry of health, labour and welfare (2014): Iyakuhinnkaihatsu ni okeru seitaisiryoutyuuyakubutunoudobunnsekihou (riganndoketugouhou) no baride-syonn ni kannsuru gaidorainn. (in Japanese), https://www.pmda.go.jp/files/000206206.pdf

4. Fujimori, H. and Cobb, D.P. (1965): Central nervous system depressant activity of MA1337, 3-(3-(4-m-Chlorophenyl-1-piperazyl)propyl)-2,4(1H,3H)quinazolinedione hydrochloride. J. Pharmacol. Exp. Ther., 148, 151-157.

5. Guidelines of analysis reports for physiologically based pharmacokinetic models, ministry of health, labour and welfare (2020): Seirigakutekiyakubutsusokudoronn moderu no kaisekihoukokusho ni kannsuru gaidorainn. (in Japanese), https://www.pmda.go.jp/files/000238191.pdf

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