PHYSICOCHEMICAL AND CELL-BASED APPROACH FOR EARLY SCREENING OF PHOSPHOLIPIDOSIS-INDUCING POTENTIAL
Author:
Affiliation:
1. Worldwide Safety Sciences
2. Worldwide Pharmaceutical Sciences
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
http://www.jstage.jst.go.jp/article/jts/31/4/31_4_315/_pdf
Reference28 articles.
1. Cytotoxicity and lamellar body induction potential of a racemic benzamide antiarrhythmic compound and enantiomers in cultured rat hepatocytes
2. Analysis of two matrix metalloproteinase inhibitors and their metabolites for induction of phospholipidosis in rat and human hepatocytes11Abbreviations: MMP, matrix metalloproteinase; MMPI, matrix metalloproteinase inhibitor; DMEM, Dulbecco’s modified Eagle’s medium; FBS, fetal bovine serum; NBD-PE, N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine; and MTT, 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide; DMSO, dimethylsulfoxide; HPLC, high performance liquid chromatography.
3. Cationic Amphiphilic Drug-Induced Phospholipidosis
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