Establishment of hyperoxic cell culture system for predicting drug-induced liver injury: reducing accumulated lipids in hepatocytes derived from chimeric mice with humanized liver

Author:

Ohtsuki Yuya1,Sanoh Seigo1,Yamao Mikaru2,Kojima Yuha2,Kotake Yaichiro1,Tateno Chise3

Affiliation:

1. Graduate School of Biomedical and Health Sciences, Hiroshima University

2. Research and Development Department, PhoenixBio Co., Ltd.

3. School of Pharmaceutical Sciences, Wakayama Medical University

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference27 articles.

1. Albrecht, W., Kappenberg, F., Brecklinghaus, T., Stoeber, R., Marchan, R., Zhang, M., Ebbert, K., Kirschner, H., Grinberg, M., Leist, M., Moritz, W., Cadenas, C., Ghallab, A., Reinders, J., Vartak, N., van Thriel, C., Golka, K., Tolosa, L., Castell, J.V., Damm, G., Seehofer, D., Lampen, A., Braeuning, A., Buhrke, T., Behr, A.C., Oberemm, A., Gu, X., Kittana, N., van de Water, B., Kreiling, R., Fayyaz, S., van Aerts, L., Smedsrød, B., Ellinger-Ziegelbauer, H., Steger-Hartmann, T., Gundert-Remy, U., Zeigerer, A., Ullrich, A., Runge, D., Lee, S.M., Schiergens, T.S., Kuepfer, L., Aguayo-Orozco, A., Sachinidis, A., Edlund, K., Gardner, I., Rahnenführer, J. and Hengstler, J.G. (2019): Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Arch. Toxicol., 93, 1609-1637.

2. Choudhry, H. and Harris, A.L. (2018): Advances in Hypoxia-Inducible Factor Biology. Cell Metab., 27, 281-298.

3. Donato, M.T., Tolosa, L., Jiménez, N., Castell, J.V. and Gómez-Lechón, M.J. (2012): High-content imaging technology for the evaluation of drug-induced steatosis using a multiparametric cell-based assay. J. Biomol. Screen., 17, 394-400.

4. Godoy, P., Hewitt, N.J., Albrecht, U., Andersen, M.E., Ansari, N., et al. (2013): Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. Arch. Toxicol., 87, 1315-1530.

5. Hornberg, J.J., Laursen, M., Brenden, N., Persson, M., Thougaard, A.V., Toft, D.B. and Mow, T. (2014): Exploratory toxicology as an integrated part of drug discovery. Part I: why and how. Drug Discov. Today, 19, 1131-1136.

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