Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol-Reference-Cited by-同舟云学术

Relative contribution of rat CYP isoforms responsible for stereoselective metabolism of carvedilol

Published:2018 Issue:1 Volume:43 Page:59-63
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Iwaki Masahiro¹,Niwa Toshiro¹²,Nakamura Yukiko¹,Kawase Atsushi¹,Komura Hiroshi¹

Affiliation:

1. Department of Pharmacy, Faculty of Pharmacy, Kindai University

2. School of Pharmacy, Shujitsu University,

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/43/1/43_59/_pdf

Reference16 articles.

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2. Eagling, V.A., Tjia, J.F. and Back, D.J. (1998): Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br. J. Clin. Pharmacol., 45, 107-114.

3. Fisker, F.Y., Grimm, D. and Wehland, M. (2015): Third-generation beta-adrenoceptor antagonists in the treatment of hypertension and heart failure. Basic Clin. Pharmacol. Toxicol., 117, 5-14.

4. Fujimaki, M. (1994): Oxidation of R(+)- and S(-)-carvedilol by rat liver microsomes. Evidence for stereoselective oxidation and characterization of the cytochrome P450 isozymes involved. Drug Metab. Dispos., 22, 700-708.

5. Hasegawa, T., Eiki, J. and Chiba, M. (2014): Interindividual variations in metabolism and pharmacokinetics of 3-(6-methylpyridine-3-yl-sulfanyl)-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(1,3-thiazole-2-yl)-2-pyridine carboxamide, a glucokinase activator, in rats caused by the genetic polymorphism of CYP2D1. Drug Metab. Dispos., 42, 1548-1555.

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