A novel screening test to predict the developmental toxicity of drugs using human induced pluripotent stem cells

Author:

Aikawa Nobuo1

Affiliation:

1. Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference41 articles.

1. Agwuh, K.N. and MacGowan, A. (2006): Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J. Antimicrob. Chemother., 58, 256-265.

2. Aikawa, N., Kunisato, A., Nagao, K., Kusaka, H., Takaba, K. and Ohgami, K. (2014): Detection of thalidomide embryotoxicity by in vitro embryotoxicity testing based on human iPS cells. J. Pharmacol. Sci., 124, 201-207.

3. Aikawa, N., Suzuki, Y. and Takaba, K. (2015): A simple protocol for the myocardial differentiation of human iPS cells. Biol. Pharm. Bull., 38, 1070-1075.

4. Annett, J.R., Agnieszka, S. and Manuela, F. (2016): The European Union Reference laboratories (EURL)-the European Center for the Validation of Alternative Methods (ECVAM) database service on alternative methods to animal experimentation, protocol No. 113: embryonic stem cell test (EST).

5. Briggs, G.G., Freeman, R.K. and Yaffe, S.J. (2011): A reference guide to fetal and neonate risk. In: Drugs in pregnancy and Lactation 9th edition, pp.772-773, Lippincott Williams & Wilkins, Philadelphia.

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