Preexisting diabetes mellitus had no effect on the no-observed-adverse-effect-level of acetaminophen in rats
Author:
Affiliation:
1. Department of Gastroenterology, IMS Sapporo Digestive Disease Center General Hospital
2. Oncology Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/45/3/45_151/_pdf
Reference24 articles.
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2. Amiri, L., John, A., Shafarin, J., Adeghate, E., Jayaprakash, P., Yasin, J., Howarth, F.C. and Raza, H. (2015): Enhanced Glucose Tolerance and Pancreatic Beta Cell Function by Low Dose Aspirin in Hyperglycemic Insulin-Resistant Type 2 Diabetic Goto-Kakizaki (GK). Rats. Cell. Physiol. Biochem., 36, 1939-1950.
3. Barbier-Torres, L., Iruzubieta, P., Fernández-Ramos, D., Delgado, T.C., Taibo, D., Guitiérrez-de-Juan, V., Varela-Rey, M., Azkargorta, M., Navasa, N., Fernández-Tussy, P., Zubiete-Franco, I., Simon, J., Lopitz-Otsoa, F., Lachiondo-Ortega, S., Crespo, J., Masson, S., McCain, M.V., Villa, E., Reeves, H., Elortza, F., Lucena, M.I., Hernández-Alvarez, M.I., Zorzano, A., Andrade, R.J., Lu, S.C., Mato, J.M., Anguita, J., Rincón, M. and Martínez-Chantar, M.L. (2017): The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury. Nat. Commun., 8, 2068.
4. Burin, G.J. and Saunders, D.R. (1999): Addressing human variability in risk assessment--the robustness of the intraspecies uncertainty factor. Regul. Toxicol. Pharmacol., 30, 209-216.
5. Dorne, J.L. (2010): Metabolism, variability and risk assessment. Toxicology, 268, 156-164.
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