Lack of human relevance for rat developmental toxicity of flumioxazin is revealed by comparative heme synthesis assay using embryonic erythroid cells derived from human and rat pluripotent stem cells
Author:
Affiliation:
1. Environmental Health Science Laboratory, Sumitomo Chemical Co., Ltd.
2. Bioscience Research Laboratory, Sumitomo Chemical Co., Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/47/4/47_125/_pdf
Reference40 articles.
1. Abe, J., Isobe, N., Mikata, K., Nagahori, H., Naito, Y., Saji, H., Ono, M. and Kawamura, S. (2018): Flumioxazin metabolism in pregnant animals and cell-based protoporphyrinogen IX oxidase (PPO) inhibition assay of fetal metabolites in various animal species to elucidate the mechanism of the rat-specific developmental toxicity. Toxicol. Appl. Pharmacol., 339, 34-41.
2. Arakawa, A., Otani, M., Iwashita, K. and Yamazaki, K. (2017): Molecular dynamics mechanism to generate species differences in inhibition of protoporphyrinogen oxidase by flumioxazin. Comput. Toxicol., 1, 12-21.
3. Buehr, M., Meek, S., Blair, K., Yang, J., Ure, J., Silva, J., McLay, R., Hall, J., Ying, Q.L. and Smith, A. (2008): Capture of authentic embryonic stem cells from rat blastocysts. Cell, 135, 1287-1298.
4. Chang, K.H., Nelson, A.M., Cao, H., Wang, L., Nakamoto, B., Ware, C.B. and Papayannopoulou, T. (2006): Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Blood, 108, 1515-1523.
5. Clark, R.L., Arima, A., Makori, N., Nakata, Y., Bernard, F., Gristwood, W., Harrell, A., White, T.E. and Wier, P.J. (2008): Artesunate: developmental toxicity and toxicokinetics in monkeys. Birth Defects Res. B Dev. Reprod. Toxicol., 83, 418-434.
Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Human Stem Cells for Cardiac Disease Modeling and Preclinical and Clinical Applications—Are We on the Road to Success?;Cells;2023-06-27
2. Flumioxazin, a PPO inhibitor: A weight-of-evidence consideration of its mode of action as a developmental toxicant in the rat and its relevance to humans;Toxicology;2022-04
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