Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3–dependent cytotoxicity

Author:

Luo Jia1,Gurung Sonam1,Lee Laura1,Henley Jeremy M1,Wilkinson Kevin A1,Guo Chun12

Affiliation:

1. School of Biochemistry, Centre for Synaptic Plasticity, Biomedical Sciences Building, University of Bristol, U.K.

2. Present address: Department of Biomedical Science, University of Sheffield, U.K.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference29 articles.

1. Adiele, R.C., Stevens, D. and Kamunde, C. (2011): Cadmium- and calcium-mediated toxicity in rainbow trout (Oncorhynchus mykiss) in vivo: interactions on fitness and mitochondrial endpoints. Chemosphere, 85, 1604-1613.

2. Anderson, C.A. and Blackstone, C. (2013): SUMO wrestling with Drp1 at mitochondria. EMBO J., 32, 1496-1498.

3. Byrnes, K.R., Stoica, B.A., Fricke, S., Di Giovanni, S. and Faden, A.I. (2007): Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain, 130, 2977-2992.

4. Chang, C.R. and Blackstone, C. (2010): Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1. Ann. N Y Acad. Sci., 1201, 34-39.

5. Cimarosti, H., Ashikaga, E., Jaafari, N., Dearden, L., Rubin, P., Wilkinson, K.A. and Henley, J.M. (2012): Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones. J. Cereb. Blood Flow Metab., 32, 17-22.

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