Time-dependent changes in serum concentrations of acyclovir and its metabolite, 9-carboxymethoxymethylguanine, in a patient with suspected acyclovir encephalopathy

Author:

Abe Kazumasa1,Kaizaki-Mitsumoto Asuka2,Saito Tomohiro3,Sugiyama Motonori3,Honda Hirokazu3,Numazawa Satoshi2

Affiliation:

1. Department of Hospital Pharmaceutics, Showa University School of Pharmacy

2. Division of Toxicology, Department of Pharmacology, Toxicology and Therapeutics, Showa University School of Pharmacy

3. Division of Nephrology, Department of Medicine, Showa University School of Medicine

Publisher

Japanese Society of Toxicology

Reference9 articles.

1. Azuma, J., Aoki, T., Yamamoto, I., Seto, Y., Tokuda, K., Horiuchi, M., Sato, H., Mano, A., Ogawa, K. and Ootani, Y. (1998): A Phase I Study of a New Antiviral Drug, Valaciclovir Hydrochloride(256U87), in Healthy Male Volunteers. Rinsho Iyaku, 14, 2683-2700.

2. Helldén, A., Odar-Cederlöf, I., Diener, P., Barkholt, L., Medin, C., Svensson, J., Säwe, J. and Ståhle, L. (2003): High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol. Dial. Transplant., 18, 1135-1141.

3. Helldén, A., Lycke, J., Vander, T., Svensson, J., Odar-Cederlöf, I. and Ståhle, L. (2006): The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment. J. Antimicrob. Chemother., 57, 945-949.

4. Iijima, M., Hasegawa, T., Shibata, S., Miyakawa, H. and Uchigata, M. (2003): Neurotoxicity of valacyclovir in a patient on hemodialysis. Neurol. Med., 58, 327-329.

5. Kokubo, T., Hirata, J., Oota, M., Fujita, M. and Yamakawa, T. (2004): Relationship between acyclovir pharmacokinetics and neuropsychiatric adverse effects in dialysis patients. [Translated from Japanese.] Tousekikanjya ni okeru acyclovir tainaidoutai to seishinshinkeikei no yuugaisayouhatugen no kanrensei. Journal of Osaka Society for Dialysis Therapy., 22, 153-157. (in Japanese.)

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