Physiological and drug-induced changes in blood levels of adrenal steroids and their precursors in cynomolgus monkeys: An application of steroid profiling by LC–MS/MS for evaluation of the adrenal toxicity
Author:
Affiliation:
1. Preclinical Research Unit, Sumitomo Dainippon Pharma Co., Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/44/9/44_575/_pdf
Reference26 articles.
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2. Chung, S., Son, G.H. and Kim, K. (2011): Circadian rhythm of adrenal glucocorticoid: its regulation and clinical implications. Biochim. Biophys. Acta, 1812, 581-591.
3. Cooke, C.R., Whelton, P.K., Moore, M.A., Caputo, R.A., Bledsoe, T. and Walker, W.G. (1979): Dissociation of the diurnal variation of aldosterone and cortisol in anephric subjects. Kidney Int., 15, 669-675.
4. Engelhardt, D., Dörr, G., Jaspers, C. and Knorr, D. (1985): Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11 beta-hydroxylase. Klin. Wochenschr., 63, 607-612.
5. Engelhardt, D., Weber, M.M., Miksch, T., Abedinpour, F. and Jaspers, C. (1991): The influence of ketoconazole on human adrenal steroidogenesis: incubation studies with tissue slices. Clin. Endocrinol. (Oxf.), 35, 163-168.
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