Effect of pharmacokinetic profile on the pancreatic toxicity and efficacy of tacrolimus in rats

Author:

Mitamura Takashi1,Yamada Atsushi1,Hanaoka Kaori2,Asano Masayuki3,Niwa Toshiro3,Seki Jiro1

Affiliation:

1. Drug Safety Research Laboratories, Astellas Pharma Inc.

2. Applied Pharmacology Research Laboratories, Astellas Pharma Inc.

3. Medical Science Research, Astellas Pharma Inc.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference23 articles.

1. Abu-Elmagd, K.M., Fung, J., Draviam, R., Shannon, W., Jain, A., Alessiani, M., Takaya, S., Venkataramanan, R., Warty V.S., Tzakis, A., Todo, S. and Starzl, T.E. (1991): Four-hour versus 24-hour intravenous infusion of FK 506 in liver transplantation. Transplant. Proc., 23, 2767-2770.

2. Alloway, R., Steinberg, S., Khalil, K., Gourishankar, S., Miller, J., Norman, D., Hariharan, S., Pirsch, J., Matas, A., Zaltzman, J., Wisemandle, K., Fitzsimmons, W. and First, M.R. (2005): Conversion of stable kidney transplant recipients from a twice daily Prograf-based regimen to a once daily modified release tacrolimus-based regimen. Transplant. Proc., 37, 867-870.

3. Dansirikul, C., Staatz, C.E., Duffull, S.B., Taylor, P.J., Lynch, S.V. and Tett, S.E. (2006): Relationships of tacrolimus pharmacokinetic measures and adverse outcomes in stable adult liver transplant recipients. J. Clin. Pharm. Ther., 31, 17-25.

4. Didlake, R.H., Dreyfus, K., Kerman, R.H., Van Buren, C.T. and Kahan, B.D. (1988): Patient noncompliance: a major cause of late graft failure in cyclosporine-treated renal transplants. Transplant. Proc., 20, 63-69.

5. Fennell, R.S., Foulkes, L.M. and Boggs, S.R. (1994): Family-based program to promote medication compliance in renal transplant children. Transplant. Proc., 26, 102-103.

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