Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity-Reference-Cited by-同舟云学术

Increase in covalent binding of 5-hydroxydiclofenac to hepatic tissues in rats co-treated with lipopolysaccharide and diclofenac: involvement in the onset of diclofenac-induced idiosyncratic hepatotoxicity

Published:2012 Issue:6 Volume:37 Page:1143-1156
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Kishida Tomoyuki¹,Onozato Tomoya¹,Kanazawa Toru¹,Tanaka Satoru¹,Kuroda Junji¹

Affiliation:

1. Safety Research Laboratory, R&D, Kissei Pharmaceutical Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/37/6/37_1143/_pdf

Reference40 articles.

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3. Beutler, B. and Rietschel, E.T. (2003): Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol., 3, 169-176.

4. Boelsterli, U.A. (2003): Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Toxicol. Applied. Pharmacol., 192, 307-322.

5. Bort, R., Ponsoda, X., Jover, R., Gomez-Lechon, M.J. and Castell, J.V. (1999): Diclofenac toxicity to hepatocytes: A role for drug metabolism in cell toxicity. J. Pharmacol. Exp. Ther., 288, 65-72.

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