Hepatic gene expression analysis of 2-aminoanthracene exposed Fisher-344 rats reveal patterns indicative of liver carcinoma and type 2 diabetes

Author:

Gato Worlanyo E.1,Hales Dale B.2,Means Jay C.1

Affiliation:

1. Department of Chemistry and Biochemistry, Southern Illinois University Carbondale, USA

2. Department of Physiology, Southern Illinois University Carbondale, School of Medicine1125 Lincoln Drive, USA

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference42 articles.

1. Affymetrix (2008/9), Affymetrix GeneChip® Expression Analysis Technical Manual.

2. Agency for Toxic Substances and Disease Registry (ATSDR) (1995): Toxicological profile for polycyclic aromatic hydrocarbons (PAHs). US Department of Health and Human Services, Public Health Service. Atlanta GA. <http://www.atsdr.cdc.gov/ToxProfiles/tp69.pdf>

3. Berger, J. and Moller, D.E. (2002): The mechanisms of action of PPARs. Annu. Rev. Med., 53, 409-435.

4. Bio-Rad Laboratories Inc., Experion™ RNA StdSens Analysis Kit; iScript one-step RT-PCR kit; SsoFast™ EvaGreen® Supermix. Hercules, CA.

5. Boudreau, M.D., Taylor, H.W., Baker, D.G. and Means, J.C. (2006): Dietary exposure to 2-aminoanthracene induces morphological and immunocytochemical changes in pancreatic tissues of Fisher-344 rats. Toxicol. Sci., 93, 50-61.

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