Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells-Reference-Cited by-同舟云学术

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Effects of Hsp90 inhibitors, geldanamycin and its analog, on ceramide metabolism and cytotoxicity in PC12 cells

Published:2012 Issue:5 Volume:37 Page:1049-1057
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Toyomura Kaori¹,Saito Takeshi²,Emori Syunsuke¹,Matsumoto Ikiru¹,Kato Erina¹,Kaneko Masayuki³,Okuma Yasunobu³,Nakamura Hiroyuki¹,Murayama Toshihiko¹

Affiliation:

1. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University

2. Laboratory of Environmental Health Sciences, Faculty of Health Sciences, Hokkaido University

3. Department of Pharmacology, Faculty of Pharmaceutical Sciences, Chiba Institute of Science

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/37/5/37_1049/_pdf

Reference29 articles.

1. Beljanski, V., Knaak, C. and Smith, C.D. (2010): A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J. Pharmacol. Exp. Ther., 333, 454-464.

2. Clark, C.B., Rane, M.J., El Mehdi, D., Miller, C.J., Sachleben Jr, L.R. and Gozal, E. (2009): Role of oxidative stress in geldanamycin-induced cytotoxicity and disruption of Hsp90 signaling complex. Free Radic. Biol. Med., 47, 1440-1449.

3. Doroshenko, N. and Doroshenko, P. (2007): Lanthanum suppresses arachidonic acid-induced cell death and mitochondrial depolarization in PC12 cells. Eur. J. Pharmacol., 567, 36-42.

4. Fukuyo, Y., Inoue, M., Nakajima, T., Higashikubo, R., Horikoshi, N.T., Hunt, C., Usheva, A., Freeman, M.L. and Horikoshi, N. (2008): Oxidative stress plays a critical role in inactivating mutant BRAF by geldanamycin derivatives. Cancer Res., 68, 6324-6330.

5. Gerling, N., Culmsee, C., Klumpp, S. and Krieglstein, J. (2004): The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons. Neurochem. Int., 44, 505-520.

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