A tiered approach combining the short time exposure (STE) test and the bovine corneal opacity and permeability (BCOP) assay for predicting eye irritation potential of chemicals

Author:

Hayashi Kazuhiko1,Mori Taeko1,Abo Takayuki1,Koike Mirei1,Takahashi Yutaka1,Sakaguchi Hitoshi1,Nishiyama Naohiro1

Affiliation:

1. Safety Science Research Laboratories, Kao Corporation

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference17 articles.

1. The SDA Alternatives Program Phase III: Comparison of in Vitro Data with Animal Eye Irritation Data on Solvents, Surfactants, Oxidizing Agents, and Prototype Cleaning Products

2. Balls, M., Berg, N., Bruner, L.H., Curren, R.D., De Silva, O., Earl, L.K., Esdaile, D.J., Fentem, J.H., Liebsch, M., Ohno, Y., Prinsen, M.K., Spielmann, H. and Worth, A.P. (1999): Eye irritation testing: the way forward,The report and recommendations of ECVAM workshop 34., Altern. Lab. Anim., 27, 53-77.

3. Cooper, K.R., Brown, R.S. and Chang, P.W. (1982): Accuracy of blood cytological screening techniques for the diagnosis of a possible hematopoietic neoplasm in the bivalve mollusc, Mya arenaria. J. Invertebr. Pathol., 39, 281-289.

4. Directive 2003/15/EC of the European Parliament and of the Council of 27 February 2003, Official Journal of the European Union, L66, 26-35.

5. Draize, J.H., Woodard, G. and Calvery, H.O. (1944): Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J. Pharmacol. Exp. Ther., 82, 377-390.

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