EFFECTS OF MATERNAL EXPOSURE TO A LOW DOSE OF DIETHYLSTILBESTROL ON SEXUAL DIMORPHIC NUCLEUS VOLUME AND MALE REPRODUCTIVE SYSTEM IN RAT OFFSPRING

Author:

YAMAMOTO Masako1,SHIRAI Mitsuyuki2,TAMURA Aya1,KOBAYASHI Tetsuo1,KOHARA Shinnya1,MURAKAMI Masaru3,ARISHIMA Kazuyoshi1

Affiliation:

1. Department of Anatomy II

2. Department of Veterinary Pharmacology

3. Department of Molecular Biology, Azabu University, School of Veterinary Medicine

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference35 articles.

1. Arai, Y., Mori, T., Suzuki, Y. and Bern, H.A. (1983): Long-term effects of perinatal exposure to sex steroid and diethylstilbestrol on the reproductive system of male mammals., Int. Rev. Cytol., 84, 235-268.

2. Arnold, A.P. and Gorski, R.A. (1984): Gonadal steroid induction of structural sex differences in the central nervous system. Annu. Rev. Neurosci., 7, 413-442.

3. Atanassova, N., McKinnell, C., Walker, M., Turner, K.J., Fisher, J.S., Morley, M., Millar, M.R., Groome, N.P. and Sharpe, R.M.(1999): Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood. Endocrinology, 140, 5364-5373.

4. Atanassova, N., McKinnell, C., Turner, K.J., Walker, M., Fisher, J.S., Morley, M., Millar, N.R., Groome, N.P. and Sharpe, R.M. (2000): Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and relationship to adult testis size and fertility: Evidence for stimulatory effects of low estrogen levels. Endocrinology, 141, 3898-3907.

5. Atanassova, N., McKinnell, C., Williams, K., Turner, K.J., Fisher, J.S., Saunders, P.T., Millar, M.R. and Sharpe, R.M. (2001): Age-, cell- and region-specific immunoexpression of estrogen receptor a (but not estrogen b) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol. Endocrinology, 142, 874-886.

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