CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element-Reference-Cited by-同舟云学术

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CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element

Published:2017 Issue:5 Volume:4 Page:229-239
ISSN:2189-115X
Container-title:Fundamental Toxicological Sciences
language:en
Short-container-title:Fundam. Toxicol. Sci.

Author:

Aratsu Yusuke¹²,Odagiri Reo¹,Shoji Rie¹,Watanabe Kouki¹,Kumagai Takeshi¹,Shindo Sawako¹,Sasaki Takamitsu¹³,Nagata Kiyoshi¹

Affiliation:

1. Department of Environmental Health Science, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

2. Drug Metabolism and Pharmacokinetics Research Laboratories, Central Pharmaceutical Research Institute, Japan tobacco Inc.

3. Department of Molecular Toxicology, School of Pharmaceutical Sciences, University of Shizoka

Publisher

Japanese Society of Toxicology

Link

https://www.jstage.jst.go.jp/article/fts/4/5/4_229/_pdf

Reference27 articles.

1. Bertilsson, G., Heidrich, J., Svensson, K., Asman, M., Jendeberg, L., Sydow-Bäckman, M., Ohlsson, R., Postlind, H., Blomquist, P. and Berkenstam, A. (1998): Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc. Natl. Acad. Sci. USA, 95, 12208-12213.

2. Blumberg, B., Sabbagh, W., Juguilon, H., Bolado, J., Van Meter, C.M., Ong, E.S. and Evans, R.M. (1998): SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev., 12, 3195-3205.

3. Drocourt, L., Ourlin, J.C., Pascussi, J.M., Maurel, P. and Vilarem, M.J. (2002): Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J. Biol. Chem., 277, 25125-25132.

4. Elias, A., High, A.A., Mishra, A., Sien, S., Wu, J., Peng, J. and Chen, T. (2014): Identification and characterization of phosphorylation sites within the pregnane X receptor protein. Biochem. Pharmacol., 87, 360-370.

5. EMA (2012): Guideline on the investigation of drug interactions. Guid. Doc., 44, 59.

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