Inhibition of autophagy with expression of NADPH oxidase subunit p22phox in preneoplastic lesions in a high-fat diet and streptozotocin-related hepatocarcinogenesis rat model

Author:

Ichikawa Ryo1,Masuda Sosuke1,Nakahara Junta1,Kobayashi Mio1,Yamashita Risako1,Uomoto Suzuka1,Kanami Ohshima1,Hara Erika1,Ito Yuko1,Shibutani Makoto1,Yoshida Toshinori2

Affiliation:

1. Laboratory of Veterinary Pathology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology

2. Cooperative Division of Veterinary Sciences, Tokyo University of Agriculture and Technology

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference43 articles.

1. de Lima, V.M., Oliveira, C.P., Alves, V.A., Chammas, M.C., Oliveira, E.P., Stefano, J.T., de Mello, E.S., Cerri, G.G., Carrilho, F.J. and Caldwell, S.H. (2008): A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma. J. Hepatol., 49, 1055-1061.

2. Di Malta, C., Cinque, L. and Settembre, C. (2019): Transcriptional regulation of autophagy: mechanisms and diseases. Front. Cell Dev. Biol., 7, 114.

3. Dyson, J., Jaques, B., Chattopadyhay, D., Lochan, R., Graham, J., Das, D., Aslam, T., Patanwala, I., Gaggar, S., Cole, M., Sumpter, K., Stewart, S., Rose, J., Hudson, M., Manas, D. and Reeves, H.L. (2014): Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team. J. Hepatol., 60, 110-117.

4. Eguchi, A., Mizukami, S., Nakamura, M., Masuda, S., Murayama, H., Kawashima, M., Inohana, M., Nagahara, R., Kobayashi, M., Yamashita, R., Uomoto, S., Makino, E., Ohtsuka, R., Takahashi, N., Hayashi, S.M., Maronpot, R.R., Shibutani, M. and Yoshida, T. (2022): Metronidazole enhances steatosis-related early-stage hepatocarcinogenesis in high fat diet-fed rats through DNA double-strand breaks and modulation of autophagy. Environ. Sci. Pollut. Res. Int., 29, 779-789.

5. Estes, C., Anstee, Q.M., Arias-Loste, M.T., Bantel, H., Bellentani, S., Caballeria, J., Colombo, M., Craxi, A., Crespo, J., Day, C.P., Eguchi, Y., Geier, A., Kondili, L.A., Kroy, D.C., Lazarus, J.V., Loomba, R., Manns, M.P., Marchesini, G., Nakajima, A., Negro, F., Petta, S., Ratziu, V., Romero-Gomez, M., Sanyal, A., Schattenberg, J.M., Tacke, F., Tanaka, J., Trautwein, C., Wei, L., Zeuzem, S. and Razavi, H. (2018): Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030. J. Hepatol., 69, 896-904.

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