Characterization of a rat model of moderate liver dysfunction based on alpha-naphthylisothiocyanate-induced cholestasis

Author:

Bothe Melanie K.1,Meyer Christoph1,Mueller Udo2,Queudot Jean-Christophe3,Roger Virginie4,Harleman Johannes1,Westphal Martin1

Affiliation:

1. Fresenius Kabi Deutschland GmbH, Germany

2. Biocrates Life Sciences AG, Austria

3. Charles River Laboratories, USA

4. Charles River Laboratories, France

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference18 articles.

1. Aoki, Y., Suzuki, H. and Itoh, H. (1986): Changes in polyamine metabolism in rat liver after oral administration of alpha-naphthylisothiocyanate. J. Toxicol. Sci., 11, 95-104.

2. Brown, R.S.Jr. (2000): Predicting outcome of transplantation for cholestatic liver disease: Child-Pugh or Mayo risk score? Liver Transpl., 6, 759-761.

3. Chisholm, J.W. and Dolphin, P.J. (1996): Abnormal lipoproteins in the ANIT-treated rat: a transient and reversible animal model of intrahepatic cholestasis. J. Lipid. Res., 37, 1086-1098.

4. Glaser, S.S., Onori, P., Wise, C., Yang, F., Marzioni, M., Alvaro, D., Franchitto, A., Mancinelli, R., Alpini, G., Munshi, M.K. and Gaudio, E. (2010): Recent advances in the regulation of cholangiocyte proliferation and function during extrahepatic cholestasis.Dig. Liver Dis., 42, 245-252.

5. Goldfarb, S., Singer, E.J. and Popper, H. (1962): Experimental cholangitis due to alpha-naphthyl-isothiocyanate (ANIT). Am. J. Pathol., 40, 685-698.

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