Utility of human hepatocyte spheroids for evaluation of hepatotoxicity

Author:

Ogihara Takuo12,Iwai Hisakazu13,Inoue Yukiko1,Katagi Jun14,Matsumoto Norihito14,Motoi-Ohtsuji Makiko15,Kakiki Motoharu15,Kaneda Shinya16,Nagao Takuya17,Kusumoto Kumiko18,Ozeki Emiko19,Jomura Tomoko19,Tanaka Sho110,Ueda Tadayoshi111,Ohta Kunihiro112,Ohkura Takako113,Arakawa Hiroshi12,Nagai Daichi114

Affiliation:

1. Spheroid Working Group, Safety Evaluation Forum

2. Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare

3. Drug Development Center, Sanwa Kagaku Kenkyusho Co., Ltd.

4. Department of Biology & Pharmacology, Ono Pharmaceutical Co., Ltd.

5. Drug Metabolism and Pharmacokinetics Japan, Tsukuba Research Laboratories, Eisai Co., Ltd.

6. Naruto Research Institute, Otsuka Pharmaceutical Factory, Inc.

7. Environmental Evaluation Business Division, Sumika Chemical Analysis Service, Ltd.

8. Department of Pathology, Osaka City University Medical School

9. Research and Development, Toyo Gosei Co., Ltd.

10. Safety Assessment Unit, Toxicological Laboratory, Public Interest Incorporated Foundation BioSafety Research Center

11. Research & Development Division, Dainippon Sumitomo Pharma Co., Ltd.

12. Pre-Clinical Research Department, Chugai Pharmaceutical Co., Ltd.

13. Clinical Development Division, Maruishi Pharmaceutical, Co., Ltd.

14. Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd.

Publisher

Japanese Society of Toxicology

Reference30 articles.

1. Abernethy, D.R., Greenblatt, D.J. and Shader, R.I. (1985): Imipramine and desipramine disposition in the elderly. J. Pharmacol. Exp. Ther., 232, 183-188.

2. Baraldo, M., Pea, F., Poz, D. and Furlanut, M. (2001): Pharmacokinetics of two oral cyclosporin A formulations in clinically stable heart-transplant patients. Pharmacol. Res., 43, 547-551.

3. Bort, R., Ponsoda, X., Jover, R., Gomez-Lechon, M.J. and Castell, J.V. (1999): Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. J. Pharmacol. Exp. Ther., 288, 65-72.

4. Bowsher, R.R., Compton, J.A., Kirkwood, J.A., et al. (1994): Sensitive and specific radioimmunoassay for fialuridine: initial assessment of pharmacokinetics after single oral doses to healthy volunteers. Antimicrob. Agents Chemother., 38, 2134-2142.

5. Crompton, M., Ellinger, H. and Costi, A. (1988): Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J., 255, 357-360.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3