Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies
Author:
Affiliation:
1. Department of Pharmacology, Faculty of Medicine, Toho University
2. CMIC Pharma Science Co., Ltd. Bioresearch Center
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/42/1/42_93/_pdf
Reference34 articles.
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2. Authier, S., Gervais, J., Fournier, S., Gauvin, D., Maghezzi, S. and Troncy, E. (2011): Cardiovascular and respiratory safety pharmacology in Göttingen minipigs: Pharmacological characterization. J. Pharmacol. Toxicol. Methods., 64, 53-59.
3. Bode, G., Clausing, P., Gervais, F., Loegsted, J., Luft, J., Nogues, V. and Sims, J.; Steering Group of the RETHINK Project. (2010): The utility of the minipig as an animal model in regulatory toxicology. J. Pharmacol. Toxicol. Methods., 62, 196-220.
4. Cao, X., Nakamura, Y., Wada, T., Izumi-Nakaseko, H., Ando, K. and Sugiyama, A. (2016): Electropharmacological effects of amantadine on cardiovascular system assessed with J-Tpeak and Tpeak-Tend analysis in the halothane-anesthetized beagle dogs. J. Toxicol. Sci., 41, 439-447.
5. Forster, R., Bode, G., Ellegaard, L. and van der Laan, J.W. (2010): The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: conclusions and recommendations. J. Pharmacol. Toxicol. Methods., 62, 236-242.
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