Activation of PTP1B/EGFR signaling and cytotoxicity during combined exposure to ambient electrophiles in A431 cells

Author:

Abiko Yumi1,Kurosawa Kohki2,Yamakawa Hiroto2,Kumagai Yoshito12

Affiliation:

1. Faculty of Medicine, University of Tsukuba

2. Master’s Program of Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference31 articles.

1. Abdelmohsen, K., Gerber, P.A., von Montfort, C., Sies, H. and Klotz, L.O. (2003): Epidermal growth factor receptor is a common mediator of quinone-induced signaling leading to phosphorylation of connexin-43: role of glutathione and tyrosine phosphatases. J. Biol. Chem., 278, 38360-38367.

2. Abiko, Y., Aoki, H. and Kumagai, Y. (2021): Effect of combined exposure to environmental aliphatic electrophiles from plants on Keap1/Nrf2 activation and cytotoxicity in HepG2 cells: A model of an electrophile exposome. Toxicol. Appl. Pharmacol., 413, 115392.

3. Abiko, Y., Luong, N.C. and Kumagai, Y. (2015): A Biotin-PEAC5-maleimide labeling assay to detect electrophiles. J. Toxicol. Sci., 40, 405-411.

4. Abiko, Y., Shinkai, Y., Unoki, T., Hirose, R., Uehara, T. and Kumagai, Y. (2017): Polysulfide Na2S4 regulates the activation of PTEN/Akt/CREB signaling and cytotoxicity mediated by 1,4-naphthoquinone through formation of sulfur adducts. Sci. Rep., 7, 4814.

5. Bae, Y.S., Kang, S.W., Seo, M.S., Baines, I.C., Tekle, E., Chock, P.B. and Rhee, S.G. (1997): Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation. J. Biol. Chem., 272, 217-221.

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