Focused DNA microarray analysis for sex-dependent gene expression of drug metabolizing enzymes, transporters and nuclear receptors in rat livers and kidneys
Author:
Affiliation:
1. Toxicology and Pharmacokinetics Laboratories, Pharmaceutical Research Laboratories, Toray Industries, Inc.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/37/4/37_863/_pdf
Reference28 articles.
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2. Ahluwalia, A., Clodfelter, K.H. and Waxman, D.J. (2004): Sexual dimorphism of rat liver gene expression: regulatory role of growth hormone revealed by deoxyribonucleic Acid microarray analysis. Mol. Endocrinol., 18, 747-760.
3. Anderson, G.D. (2005): Sex and racial differences in pharmacological response: Where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics. J. Womens Health (Larchmt) 14, 19-29.
4. Bock, K.W. and Bock-Hennig, B.S. (2010): UDP-glucuronosyltransferases (UGTs): from purification of Ah-receptor-inducible UGT1A6 to coordinate regulation of subsets of CYPs, UGTs, and ABC transporters by nuclear receptors. Drug Metab. Rev., 42, 6-13.
5. Bouthillier, L., Greselin, E., Brodeur, J., Viau, C. and Charbonneau, M. (1991) : Male rat specific nephrotoxicity resulting from subchronic administration of hexachlorobenzene. Toxicol. Appl. Pharmacol., 110, 315-326.
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