Drug-induced lenticular opacity and accumulation of cholesterol-related substances in the lens cortex of dogs
Author:
Affiliation:
1. Drug Safety Laboratories, Research Center, Taisho Pharmaceutical Co., Ltd.
2. Pharmacokinetics Laboratories, Research Center, Taisho Pharmaceutical Co., Ltd.
Publisher
Japanese Society of Toxicology
Subject
Toxicology
Link
https://www.jstage.jst.go.jp/article/jts/45/4/45_201/_pdf
Reference32 articles.
1. Bassnett, S., Shi, Y. and Vrensen, G.F. (2011): Biological glass: structural determinants of eye lens transparency. Philos. Trans. R. Soc. Lond. B Biol. Sci., 366, 1250-1264.
2. Bron, A.J., Sparrow, J., Brown, N.A., Harding, J.J. and Blakytny, R. (1993): The lens in diabetes. Eye (Lond.), 7, 260-275.
3. Cenedella, R.J. and Bierkamper, G.G. (1979): Mechanism of cataract production by 3-beta(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: an inhibitor of cholesterol biosynthesis. Exp. Eye Res., 28, 673-688.
4. Cenedella, R.J. (1996): Cholesterol and cataracts. Surv. Ophthalmol., 40, 320-337.
5. De Vries, A.C., Vermeer, M.A., Bredman, J.J., Bär, P.R. and Cohen, L.H. (1993): Cholesterol content of the rat lens is lowered by administration of simvastatin, but not by pravastatin. Exp. Eye Res., 56, 393-399.
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