Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense-Reference-Cited by-同舟云学术

Possible nonimmunological toxicological mechanisms of vesnarinone-associated agranulocytosis in HL-60 cells: role of reduced glutathione as cytotoxic defense

Published:2024 Issue:3 Volume:49 Page:95-103
ISSN:0388-1350
Container-title:The Journal of Toxicological Sciences
language:en
Short-container-title:J. Toxicol. Sci.

Author:

Koga Toshihisa¹,Sahara Yuko¹,Ohtani Tadaaki¹,Yosuke Kaneko¹,Umehara Ken¹

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

Publisher

Japanese Society of Toxicology

Link

https://www.jstage.jst.go.jp/article/jts/49/3/49_95/_pdf

Reference27 articles.

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2. Alvir, J.M., Lieberman, J.A., Safferman, A.Z., Schwimmer, J.L. and Schaaf, J.A. (1993): Clozapine-induced agranulocytosis. Incidence and risk factors in the United States. N. Engl. J. Med., 329, 162-167.

3. Aratani, Y. (2018): Myeloperoxidase: its role for host defense, inflammation, and neutrophil function. Arch. Biochem. Biophys., 640, 47-52.

4. Bertolet, B.D., White, B.G. and Pepine, C.J. (1994): Neutropenia occurring during treatment with vesnarinone (OPC-8212). Am. J. Cardiol., 74, 968-970.

5. Bertolet, B.D. (2004): Precautions for use and adverse effects of vesnarinone: potential mechanisms and future therapies. Drug Saf., 27 (Suppl 1), 11-18.

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