Retinal toxicity induced by small-molecule Hsp90 inhibitors in beagle dogs

Author:

Kanamaru Chisako1,Yamada Yuichiro1,Hayashi Shuji1,Matsushita Tomochika1,Suda Atsushi1,Nagayasu Miho1,Kimura Kazuya1,Chiba Shuichi1

Affiliation:

1. Research Division, Chugai Pharmaceutical Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference34 articles.

1. Arruda-Carvalho, M., Njaine, B., Silveira, M.S., Linden, R. and Chiarini, L.B. (2007): Hop/STI1 modulates retinal proliferation and cell death independent of PrPC. Biochem. Biophys. Res. Commun., 361, 474-480.

2. Bagatell, R., Khan, O., Paine-Murrieta, G., Taylor, C.W., Akinaga, S. and Whitesell, L. (2001): Destabilization of steroid receptors by heat shock protein 90-binding drugs: a ligand-independent approach to hormonal therapy of breast cancer. Clin. Cancer Res., 7, 2076-2084.

3. Bonting, S.L., Caravaggio, L.L. and Gouras, P. (1961): The rhodopsin cycle in the developing vertebrate retina. I. Relation of rhodopsin content, electroretinogram and rod structure in the rat. Exp. Eye Res., 1, 14-24.

4. Burrows, F., Zhang, H. and Kamal, A. (2004): Hsp90 activation and cell cycle regulation. Cell Cycle, 3, 1530-1536.

5. Chen, B., Zhong, D. and Monteiro, A. (2006): Comparative genomics and evolution of the HSP90 family of genes across all kingdoms of organisms. BMC Genomics, 7, 156.

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