Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase

Author:

Yokouchi Chie12,Nishimura Yukari3,Goto Hirohiko3,Sato Makoto3,Hidoh Yuya1,Takeuchi Kenji1,Ishii Yuji2

Affiliation:

1. Department of Drug Metabolism and Pharmacokinetics, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

2. Division of Pharmaceutical Cell Biology, Graduate School of Pharmaceutical Sciences, Kyushu University

3. Department of Drug Safety, Nonclinical Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd.

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference48 articles.

1. Aksoy, S., Szumlanski, C.L. and Weinshilboum, R.M. (1994): Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem., 269, 14835-14840.

2. Bhala, N., Angulo, P., van der Poorten, D., Lee, E., Hui, J.M., Saracco, G., Adams, L.A., Charatcharoenwitthaya, P., Topping, J.H., Bugianesi, E., Day, C.P. and George, J. (2011): The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology, 54, 1208-1216.

3. Browning, J.D., Szczepaniak, L.S., Dobbins, R., Nuremberg, P., Horton, J.D., Cohen, J.C., Grundy, S.M. and Hobbs, H.H. (2004): Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology, 40, 1387-1395.

4. Bryniarski, K., Biedron, R., Jakubowski, A., Chlopicki, S. and Marcinkiewicz, J. (2008): Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. Eur. J. Pharmacol., 578, 332-338.

5. Cantoni, G.L. (1951): Activation of methionine for transmethylation. J. Biol. Chem., 189, 745-754.

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