Enhanced hepatocarcinogenicity by combined inhalation and oral exposures to N,N-dimethylformamide in male rats

Author:

Ohbayashi Hisao1,Umeda Yumi1,Senoh Hideki1,Kasai Tatsuya1,Kano Hirokazu1,Nagano Kasuke1,Arito Heihachiro1,Fukushima Shoji1

Affiliation:

1. Japan Bioassay Research Center, Japan Industrial Safety and Health Association

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference21 articles.

1. Amster, M.B., Hijazi, N. and Chan, R. (1983): Real time monitoring of low level air contaminants from hazardous waste sites. In National conference on management of uncontrolled hazardous waste sites, pp.98-99, Hazardous materials control research institute/ consultants, Washington, DC, Silver Spring, MD.

2. Butterworth, B.E., Popp, J.A., Conolly, R.B. and Goldsworthy, T.L. (1992): Chemically induced cell proliferation in carcinogenesis. In Mechanisms of carcinogenesis in risk identification (Vainio, H., Magee, P.N., McGregor, D.B. and McMichael A.J., eds.), IARC Scientific Publication, Number 116, pp.279-305, IARC, Lyon.

3. Chemical Daily (2008): N,N-dimethylformamide. In Chemical products handbook 15308. pp.528-529, The Chemical Daily Co., Tokyo.

4. Metabolism of N,N-dimethylformamide: Key to the understanding of its toxicity

5. International Agency for Research on Cancer (IARC) (1999): Dimethylformamide. In IARC monographs on the evaluation of the carcinogenic risks to humans. re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide. Vol. 71 (Part Two), pp.545-574, IARC, Lyon.

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