Induction of mesothelioma by a single intrascrotal administration of multi-wall carbon nanotube in intact male Fischer 344 rats

Author:

Sakamoto Yoshimitsu1,Nakae Dai12,Fukumori Nobutaka1,Tayama Kuniaki1,Maekawa Akihiko23,Imai Kiyoshi4,Hirose Akihiko5,Nishimura Tetsuji6,Ohashi Norio1,Ogata Akio1

Affiliation:

1. Department of Environmental Health and Toxicology, Tokyo Metropolitan Institute of Public Health

2. Tokyo University of Agriculture

3. Safety Assessment Division, Chemical Management Center, National Institute of Technology and Evaluation

4. Biosafety Research Center Foods, Drugs and Pesticides

5. Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences

6. Division of Environmental Chemistry, National Institute of Health Sciences

Publisher

Japanese Society of Toxicology

Subject

Toxicology

Reference39 articles.

1. A Trial on the Quantitative Risk Assessment of Man-Made Mineral Fibers by the Rat Intraperitoneal Administration Assay using the JFM Standard Fibrous Samples.

2. Bernstein, D.M. and Riego Sintes, J.M. (1999): Method for the determination of the hazardous properties for human health of man made mineral fibres (MMMF). In: European Commission Joint Research Centre. Institute for Health and Consumer Protection, Unit: Toxicology and Chemicalsubstances. European Chemicals Bureau. pp.44-45.

3. Blobel, G.A., Moll, R., Franke, W.W., Kayser, K.W. and Gould, V.E. (1985): The intermediate filament cytoskelton of malignant mesothelioma and its diagnostic significance. Am. J. Pathol., 121, 235-247.

4. Cullen, R.T., Miller, B.G., Clark, S. and Davis, J.M. (2002): Tumorigenicity of cellulose fibers injected into the rat peritoneal cavity. Inhal. Toxicol., 14, 685-703.

5. Davis, J.M.G. (1976): Structural variations between pleural and peritoneal mesotheliomas produced in rats by the injection of crocidolite asbestos. Ann. Anat. Pathol., 21, 199-210.

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