Epithelium-dependent and -independent inhibitory effects of sivelestat, a neutrophil elastase inhibitor, on substance P-induced contraction of airway smooth muscle in lipopolysaccharide-treated guinea-pigs
Author:
Affiliation:
1. Department of Intensive and Critical Care Medicine, Dokkyo University School of Medicine
2. Department of Pharmacology, Dokkyo University School of Medicine
Publisher
Japan Society of Smooth Muscle Research
Subject
General Medicine,Physiology
Link
http://www.jstage.jst.go.jp/article/jsmr/41/5/41_5_257/_pdf
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3. Bost, K.L., Breeding, S.A.L. and Pascual, D.W. (1992). Modulation of the mRNAs encoding substance P and its receptor in rat macrophages by LPS. Region. Immunol. 4: 105-112.
4. Brigham, K.L. and Meyrick, B. (1986). Endotoxin and lung injury. Am. Rev. Respir. Dis. 133: 913-927.
5. Carr, M.J., Schechter, N.M. and Undem, B.J. (2000). Trypsin-induced, neurokinin-mediated contraction of guinea pig bronchus. Am. J. Respir. Crit. Care Med. 162: 1662-1667.
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2. Lasting inhibition of receptor-mediated calcium oscillations in pancreatic acini by neutrophil respiratory burst – A novel mechanism for secretory blockade in acute pancreatitis?;Biochemical and Biophysical Research Communications;2013-08
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