Renin-angiotensin system expression in the K562 human erythroleukaemic cell line-Reference-Cited by-同舟云学术

Renin-angiotensin system expression in the K562 human erythroleukaemic cell line

Published:2007-09 Issue:3 Volume:8 Page:145-147
ISSN:1470-3203
Container-title:Journal of the Renin-Angiotensin-Aldosterone System
language:en
Short-container-title:J Renin Angiotensin Aldosterone Syst

Author:

Koca Ebru¹,Haznedaroglu Ibrahim C²,Acar Kadir³,Beyazit Yavuz²,Aksu Salih²,Misirlioglu Muge⁴,Tuncer Serdar⁴,Sayinalp Nilgun²,Ozcebe Osman I²,Uner Aysegul⁵

Affiliation:

1. Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey,

2. Hacettepe University Medical School, Departments of Internal Medicine and Haematology, Ankara, Turkey

3. Gazi University Medical School, Department of Haematology, Ankara, Turkey

4. Metis Biotechnology, Inc., Ankara, Turkey

5. Hacettepe University Medical School, Department of Pathology, Ankara, Turkey

Abstract

Local renin-angiotensin system (RAS) may affect leukaemic cell production within the bone marrow microenvironment.Angiotensin-converting enzyme (ACE), renin, and angiotensin could influence leukaemogenesis. In this study, mRNA expressions of the major RAS components (ACE, renin, and angiotensinogen) in K562 human erythroleukaemia cell line have been searched by Real Time quantitative polymerase chain reaction. K562 blasts are multipotential, haematopoietic malignant cells that spontaneously differentiate into recognisable progenitors of the erythrocyte, granulocyte and monocytic series.We observed significant expressions of ACE, renin, and angiotensinogen in K562 leukaemic blast cells.Therefore, K562 human erythroleukaemia cell line may serve as an in vitro model to elucidate the role of RAS in leukaemia and to test the effects of RAS-affecting drugs on leukaemic cellular proliferation.

Publisher

Hindawi Limited

Subject

Endocrinology,Internal Medicine

Link

http://journals.sagepub.com/doi/pdf/10.3317/jraas.2007.019

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