Lower Expression of HNF4α and PGC1α Might Impair Rifampicin-mediated CYP3A4 Induction under Conditions Where PXR Is Overexpressed in Human Fetal Liver Cells

Author:

Takezawa Takashi,Matsunaga Tamihide,Aikawa Kaori,Nakamura Katsunori,Ohmori Shigeru

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference54 articles.

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2. 2) Thummel, K. E. and Wilkinson, G. R.: In vitro and in vivo drug interactions involving human CYP3A. Annu. Rev. Pharmacol. Toxicol., 38: 389–430 (1998).

3. 3) Domanski, T. L., Finta, C., Halpert, J. R. and Zaphiropoulos, P. G.: cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450. Mol. Pharmacol., 59: 386–392 (2001).

4. 4) Shimada, T., Yamazaki, H., Mimura, M., Inui, Y. and Guengerich, F. P.: Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J. Pharmacol. Exp. Ther., 270: 414–423 (1994).

5. 5) Li, A. P., Kaminski, D. L. and Rasmussen, A.: Substrates of human hepatic cytochrome P450 3A4. Toxicology, 104: 1–8 (1995).

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