Estimation of the Interindividual Variability of Cytochrome 2D6 Activity from Urinary Metabolic Ratios in the Literature

Author:

Ito Takashi,Kato Motohiro,Chiba Koji,Okazaki Osamu,Sugiyama Yuichi

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference41 articles.

1. Virtual clinical trials (I): Prediction of interindividual difference in bioavailability;Kato;21st Annual meeting of the Japanese Society for the Study of Xenobiotics,2006

2. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions;Bertz;Clin. Pharmacokinet.,1997

3. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry;Zanger;Naunyn. Schmiedebergs. Arch. Pharmacol.,2004

4. Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I;Zhou;Clin. Pharmacokinet.,2009

5. Evidence for a new variant CYP2D6 allele CYP2D6J in a Japanese population associated with lower in vivo rates of sparteine metabolism;Yokota;Pharmacogenetics.,1993

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