Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha are Factors Involved in Interindividual Variability in the Expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in Human Livers††This work was supported by grants-in-aid from the Ministry of Health, Labor and Welfare of Japan (Health and Labor Sciences Research Grants, Research on Human genome, Tissue Engineering; Health and Labor Sciences Research Grants, Risk Analysis Research on Food and Pharmaceuticals), and was partially supported by grants (18890044 and 17790112) from the Ministry of Education, Sciences, Sports and Culture of Japan.-Reference-Cited by-同舟云学术

Hepatocyte Nuclear Factor 1 Alpha and 4 Alpha are Factors Involved in Interindividual Variability in the Expression of UGT1A6 and UGT1A9 but not UGT1A1, UGT1A3 and UGT1A4 mRNA in Human Livers††This work was supported by grants-in-aid from the Ministry of Health, Labor and Welfare of Japan (Health and Labor Sciences Research Grants, Research on Human genome, Tissue Engineering; Health and Labor Sciences Research Grants, Risk Analysis Research on Food and Pharmaceuticals), and was partially supported by grants (18890044 and 17790112) from the Ministry of Education, Sciences, Sports and Culture of Japan.

Published:2007 Issue:5 Volume:22 Page:391-398
ISSN:1347-4367
Container-title:Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Aueviriyavit Sasitorn,Furihata Tomomi,Morimoto Kaori,Kobayashi Kaoru,Chiba Kan

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference29 articles.

1. UDP-Glucuronosyltransferases: gene structures of UGT1 and UGT2 families;Owen;Meth. Enzymol.,2005

2. Human UDP-glucuronosyltransferases: metabolism, expression, and disease;Tukey;Annu. Rev. Pharmacol. Toxicol.,2000

3. A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini;Ritter;J. Biol. Chem.,1992

4. Differential down regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer;Strassburg;Cancer Res.,1997

5. Substrate specificity of human hepatic UDP glucuronosyltransferases;Burchell;Meth. Enzymol.,2005

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Bile duct ligation elevates 5-HT levels in cerebral cortex of rats partly due to impairment of brain UGT1A6 expression and activity via ammonia accumulation;Redox Biology;2024-02

2. Regulation of Hepatic Xenosensor Function by HNF4alpha;2023-10-14

3. Development and Validation of a Proteomic Correlation Profiling Technique to Detect and Identify Enzymes Involved in Metabolism of Drugs of Concern;Drug Metabolism and Disposition;2023-05-08

4. A transcriptional regulatory network of HNF4α and HNF1α involved in human diseases and drug metabolism;Drug Metabolism Reviews;2022-07-26

5. Adenosine deaminases acting on RNA modulate the expression of the human pregnane X receptor;Drug Metabolism and Pharmacokinetics;2021-04