Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework-Reference-Cited by-同舟云学术

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Modeling and Simulation of Preclinical Cardiac Safety: Towards an Integrative Framework

Published:2009 Issue:1 Volume:24 Page:76-90
ISSN:1347-4367
Container-title:Drug Metabolism and Pharmacokinetics
language:en
Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Soubret Antoine,Helmlinger Gabriel,Dumotier Bérengère,Bibas Ruben,Georgieva Anna

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference153 articles.

1. Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine;Libby,2008

2. Analyses of dynamic Beat-to-Beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of Torsades de Pointes during QT prolongation caused by Sotalol;Fossa;Annals of Noninvasire Electrocardiology,2007

3. Thorough QT/QTc not so thorough: Removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs;Hondeghem;Journal of Cardiovascular Electrophysiology,2006

4. Use and abuse of QT and TRIaD in cardiac safety research: Importance of study design and conduct;Hondeghem;European Journal of Pharmacology,2008

5. QT and TdP-QT: an unreliable predictor of proarrhythmia;Hondeghem;Acta Cardiologica,2008

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2. In silico Study of Transmural Dispersion of Repolarization in Non-failing Human Ventricular Myocytes: Contribution to Cardiac Safety Pharmacology;British Journal of Pharmaceutical Research;2015-01-10

3. Implementation of Quantitative and Systems Pharmacology in Large Pharma;CPT: Pharmacometrics & Systems Pharmacology;2014-10

4. Computer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challenges;Europace;2014-05-01

5. Simulation of early after-depolarisation in non-failing human ventricular myocytes: Can this help cardiac safety pharmacology?;Pharmacological Reports;2013-09

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