Studies on the Metabolic Fate of M17055, a Novel Diuretic (5): Pharmacokinetics and Pharmacodynamics of Unchanged Drug in Rat and Dog After Intravenous Administration of M17055

Author:

Nakajima Hiroyuki,Naba Hiroyasu,Nakanishi Takeshi,Nakai Kiyohiko,Watanabe Takanori,Ida Keiichi,Ohzawa Nobuo

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference21 articles.

1. A novel quinolinone diuretic, M12285, and its activation mechanism through sulfate conjugation;Shinkawa;Eur. J. Pharmacol.,1992

2. Pharmacological properties of the novel highly potent diuretic 7-chloro-2,3-dihydro-1-(2-methylbenzoyl)-4(1H)-quinolinone 4-oxime-O-sulfonic acid potassium salt;Shinkawa;Arzneim.-Forsch. /Drug Res.,1992

3. Loop and distal actions of a novel diuretic, M17055;Shinkawa;Eur. J. Pharmacol.,1993

4. Studies on the metabolic fate of M17055, a novel diuretic (1): Plasma concentration and excretion of radioactivity in rat and dog after a single intravenous administration of [14 C]M17055;Nakajima;Xenobio. Metabol. and Dispos.,2001

5. Studies on the metabolic fate of M17055, a novel diuretic (2): Tissue distribution and transfer of radioactivity into fetus and milk in rat after a single intravenous administration of [14C]M17055;Nakajima;Xenobio. Metabol. and Dispos.,2001

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