Physicochemical and Pharmacokinetic Characterization of Amorphous Solid Dispersion of Tranilast with Enhanced Solubility in Gastric Fluid and Improved Oral Bioavailability

Author:

Onoue Satomi,Kojo Yoshiki,Aoki Yosuke,Kawabata Yohei,Yamauchi Yukinori,Yamada Shizuo

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference21 articles.

1. Inhibition of hypersensitivity reactions by a new drug, N(3,4-dimethoxycinnamoyl) anthranilic acid (N-5);Koda;J. Allergy Clin. Immunol.,1976

2. Inhibitory action of tranilast, an anti-allergic drug, on the release of cytokines and PGE2 from human monocytes-macrophages;Suzawa;Jpn. J. Pharmacol.,1992

3. Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells;Ikeda;Biochem. Biophys. Res. Commun.,1996

4. Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis;Uno;Hematology,2008

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