Effects of UGT1A6, UGT2B7, and CYP2C9 Genotypes on Plasma Concentrations of Valproic Acid in Chinese Children with Epilepsy

Author:

Guo Yingjie,Hu Cheng,He Xiaojing,Qiu Feng,Zhao Limei

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference28 articles.

1. Concentration-effect relationships of valproic acid;Chadwick;Clin. Pharmacokinet.,1985

2. Pharmacokinetics, drug interactions, and tolerability of valproate;DeVane;Psychopharmacol. Bull.,2003

3. Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family;Ebner;Drug Metab. Dispos.,1993

4. Contribution of CYP2C9, CYP2A6, and CYP2B6 to valproic acid metabolism in hepatic microsomes from individuals with the CYP2C9*1/*1 genotype;Kiang;Toxicol. Sci.,2006

5. Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling;Xing;Pharmacogenomics,2009

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