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Cytotoxic Effects of Benzbromarone and Its 1′-Hydroxy Metabolite in Human Hepatocarcinoma FLC4 Cells Cultured on Micro-space Cell Culture Plates

  • Published:2013 Issue:3 Volume:28 Page:265-268
  • ISSN:1347-4367
  • Container-title:Drug Metabolism and Pharmacokinetics
  • language:en
  • Short-container-title:Drug Metabolism and Pharmacokinetics

Author:

Kobayashi Kaoru,Kajiwara Eri,Ishikawa Masayuki,Mimura Hanaka,Oka Hidenobu,Ejiri Yoko,Hosoda Masaya,Chiba Kan

Publisher

Japanese Society for the Study of Xenobiotics

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology

Reference18 articles.

1. Hepatic injury caused by benzbromarone;van der Klauw;J. Hepatol.,1994

2. Fulminant hepatic failure associated with benzbromarone treatment: a case report;Arai;J. Gastroenterol. Hepatol.,2002

3. Fatal fulminant hepatic failure associated with benzbromarone;Wagayama;J. Hepatol.,2000

4. A case of fulminant hepatitis, possibly caused by benzbromarone;Suzuki;Nippon Shokakibyo Gakkai Zasshi,2001

5. A review of the common properties of drugs with idiosyncratic hepatotoxicity and the “multiple determinant hypothesis” for the manifestation of idiosyncratic drug toxicity;Li;Chem. Biol. Interact.,2002

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