Investigation of Healing Effects of Afyon Region Thermal Spring Water on Experimentally-Induced Gastritis in Mice

Abstract

In this study, 40 Albino mice were induced with ethyl alcohol to form of gastritis. In the treatment stage, control group mice were given tap water, while study group mice were given fresh water of Süreyya I hot spring. Clinical, hematological, biochemical, blood gases measurements and histopathological examinations of the gastric tissue were performed on the 1st, 7th, 14th and 21th days after the initiation of the treatment. At the end of the study, no significant difference was found between the groups in terms of body temperature (p> 0.05), whereas heart and respiratory frequencies were significantly higher in the study group animals (p <0.05). Although mean WBC, NOTR, MON, EOS and MCV decreased significantly in both groups (p <0.05), it was found that the mean of these parameters were more significant in SG at all measurement times (p <0.05). It was determined that TP, ALB and GLU levels increased in SG contrast to CG, and statistically significant decreases in AST, ALT, CK, ALP, LDH, UREA, CREA and IgG levels after the treatment. Additionally, pH, partial CO2 pressure, base deficit, bicarbonate, Ca and K levels decreased after gastritis procedure, whereas lactate, Na and Cl levels increased. Consequently, the clinical, hematological, blood biochemical parameters, blood gases and histopathological findings were evaluated as a whole, it was concluded that Süreyya I hot spring water was very successful in the treatment of gastritis.