Pallidopyramidal Syndrome and Hereditary Spastic Paraplegia common features and diagnostic approach and therapeutic considerations

Author:

BULBOACA 1,2, Corneliu Angelo1,BLIDARU Mihai2,FESTILA 4, Dana3,BOARESCU Paul Mihai2,STANESCU Ioana1

Affiliation:

1. Department of Neurology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania 2Clinical Rehabilitation Hospital, Cluj-Napoca, Romania

2. Department of Pathophysiology, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania

3. Department of Orthodontics, University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania

Abstract

The neurological diagnosis, can be, in some situations, a challenging one. Clinical presentation for neurological disease, which has no imagistic diagnosis criteria, can develop during several month or years. Therefore, the first evaluation of the patient with neurological symptoms is not always conclusive. Pallidopyramidal syndrome and hereditary spastic paraplegia (HSP) can present common features and diagnostic approach has to be careful. genetic assessment is the gold diagnosis method in some cases. Therapeutic strategies, following a correct diagnosis has to be addressed to improvement the patient's quality of life by rehabilitation methods and medication targeting the pathophysiological processes involvement. The aim of this paper is to discuss the clinical evolution and the diagnosis strategies in hereditary spastic paraplegia.

Publisher

Romanian Association of Balneology

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