Oligosaccharide-based Surfactant/Citric Acid Buffer System Stabilizes Lactate Dehydrogenase during Freeze-drying and Storage without the Addition of Natural Sugar

Author:

Ogawa Shigesaburo12,Kawai Ryuichiro2,Koga Maito2,Asakura Kouichi2,Takahashi Isao1,Osanai Shuichi2

Affiliation:

1. School of Science and Technology, Kwansei Gakuin University

2. Department of Applied Chemistry, Graduate School of Science and Technology, Keio University

Publisher

Japan Oil Chemists' Society

Subject

General Chemical Engineering,General Medicine,General Chemistry

Reference37 articles.

1. 1) Hora, M. Manufacturing fundamentals for biopharmaceuticals. in Formulation and process development strategies for manufacturing biopharmaceuticals (Jameel, F.; Hershenson, S. eds.) John Wiley & Sons, Inc., Chapter 24, pp. 589-604 (2010).

2. 2) Costantino, H. Excipients for use in lyophilized pharmaceutical peptide, protein, and other bioproducts. in Lyophilization of biopharmaceuticals (Biotechnology: Pharmaceutical Aspects series, Volume 2) (Costantino, H. R.; Pikal, M. J., eds.) American Association of Pharmaceutical Scientists. Arlington, VA, Chapter 5, pp. 139-226 (2004).

3. 3) Carpenter, J. F.; Izutsu, K. I.; Randolph, T. W. Freezing- and drying-induced perturbations of protein structure and mechanisms of protein protection by stabilizing additives. in Freeze drying/lyophilization of pharmaceutical and biological products, third edition. (Rey, L.; May, J. C., eds.), CRC Press, New York & London, Chapter 7, pp. 167-197 (2010).

4. 4) Jameel, F.; Pikal, M. J. Design of a formulation for freeze drying. in Formulation and process development strategies for manufacturing biopharmaceuticals (Jameel, F.; Hershenson, S. eds.) John Wiley & Sons, Inc., Chapter 18, pp. 459-492 (2010).

5. 5) Drummond, C. J.; Fong, C.; Krodkiewska, I.; Boyd, B. J.; Baker, I. J. A. Sugar Fatty Acid Esters. in Novel Surfactants, Preparation, Applications and Biodegradability (Holmberg, K. ed.) Surfactant science series 114, MarcelDekker, pp. 95-128 (2003).

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