人の長寿と長生きの抗酸菌;抗酸菌がゆっくりと生きて頻繁に眠るしくみから、薬剤開発への展開を考える
Author:
Affiliation:
1. Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences
Publisher
Japanese Leprosy Association
Subject
General Medicine
Link
https://www.jstage.jst.go.jp/article/hansen/92/2/92_41/_pdf
Reference22 articles.
1. 1) Tissenbaum HA, Guarente L: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001. https://doi.org:10.1038/35065638
2. 2) Vellai T, et al.: Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426: 620, 2003. https://doi.org:10.1038/426620a
3. 3) Masoro EJ: Overview of caloric restriction and ageing. Mech Ageing Dev 126: 913-922, 2005. https://doi.org:10.1016/j.mad.2005.03.012
4. 4) Colman RJ, et al.: Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 325: 201-204, 2009.
5. 5) Imai S, Armstrong CM, Kaeberlein M, Guarente L: Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800, 2000. https://doi.org:10.1038/35001622
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